|
FICOLIN 3 DEFICIENCY
|
0.720 |
GeneticVariation
|
disease |
BEFREE |
We sequenced the coding and non-coding regions of the FCN3 gene in an SLE patient with ficolin-3 deficiency not carrying the +1637delC.
|
31044336 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We sequenced the coding and non-coding regions of the FCN3 gene in an SLE patient with ficolin-3 deficiency not carrying the +1637delC.
|
31044336 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus.
|
30949171 |
2019 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Decreased Ficolin-3-mediated Complement Lectin Pathway Activation and Alternative Pathway Amplification During Bacterial Infections in Patients With Type 2 Diabetes Mellitus.
|
30949171 |
2019 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Moreover, His-tagged recombinant ficolin-3 (10 μg/ml) preferentially stained ovarian tissue sections from patients with malignant tumours compared with those from patients without.
|
30846332 |
2019 |
|
Coronary heart disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
We have investigated some factors of the innate immune system involved in the initiation or regulation of complement lectin pathway activation (MASP-1, MASP-2 MASP-3, MAp19, MAp44, ficolin-3) and related them to complications and prognosis in 190 pediatric patients undergoing CHD repair with the use of cardiopulmonary bypass (CPB).
|
30814659 |
2019 |
|
Systemic Inflammatory Response Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, patients suffering from SIRS and MODS with low ficolin-3 had a much better prognosis (91% survival vs. 37% among other patients; p = 0.007).
|
30814659 |
2019 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
We explored circulating liver-expressed lectins, ficolin-2, ficolin-3 and mannose binding lectin (MBL), as potential biomarkers for the development of HCC.
|
30798068 |
2019 |
|
Liver carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
We observed that the human hepatoma cell line HuH7.5, which is routinely used for the study of hepatotropic viruses, is deficient in expression of MBL, ficolin-2 and ficolin-3.
|
30747617 |
2019 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We observed that the human hepatoma cell line HuH7.5, which is routinely used for the study of hepatotropic viruses, is deficient in expression of MBL, ficolin-2 and ficolin-3.
|
30747617 |
2019 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Low H-ficolin concentrations were associated with IUGR (P < 0.01).
|
30672631 |
2019 |
|
Opportunistic Infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
There was no correlation between Ficolin-1 and Ficolin-3 levels and age, HIV viral load or opportunistic infections.
|
30349535 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We emphasize the role of the complement system and specifically suggest the involvement of ficolin-3 from the lectin pathway in the pathophysiology of ALS.
|
29933890 |
2018 |
|
Subarachnoid Hemorrhage
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Compared to healthy individuals, ICH and SAH patients had increased levels of H-ficolin (p = 0.04, p = 0.03), M-ficolin (both p < 0.0001), and MAp44 (both p = 0.01) at admission.
|
29675579 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to establish that secreted frizzled-related protein 4 (SFRP4) and ficolin-3 levels, which have been linked to insulin resistance and the development of T2DM, are elevated in GDM women.
|
29491225 |
2018 |
|
Gestational Diabetes
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In Conclusions, increased SFRP4 and ficolin-3 levels are significantly associated with GDM development and might be important risk factors for this pregnancy complication.
|
29491225 |
2018 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Ficolin-3 might be a biomarker for RFA treatment efficacy and a potential target for HCC immunotherapy.
|
29386009 |
2018 |
|
Lupus Nephritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
The combination of anti-ficolin-2, anti-ficolin-3, and anti-C1q demonstrated a very high specificity (98%) for the diagnosis of active LN.
|
29045037 |
2018 |
|
Gestational Diabetes
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Using binary logistic regression analysis, ficolin-3, retinol-binding protein-4 and adiponectin, but not C-reactive protein, triglyceride and free fatty acids were shown as predictive factors for GDM.
|
28445618 |
2018 |
|
Systemic Scleroderma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, H-ficolin-related innate immunity may be involved in SSc-ILD development.
|
28432700 |
2017 |
|
Lung Diseases, Interstitial
|
0.010 |
Biomarker
|
group |
BEFREE |
Therefore, H-ficolin-related innate immunity may be involved in SSc-ILD development.
|
28432700 |
2017 |
|
Liver carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Leprosy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results lead us to suggest that polymorphisms in the FCN3 gene cooperate to increase ficolin-3 concentration and that it might contribute to leprosy susceptibility by favoring M. leprae infection.
|
28241035 |
2017 |
|
Myocardial Infarction
|
0.020 |
Biomarker
|
disease |
BEFREE |
Ficolin-1, ficolin-3 and MAP-1 were not associated with MI.
|
28216633 |
2017 |
|
MASP2 Deficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
In Kaplan-Meier analysis, development of CSI was associated with low level of FCN-2 (<427 ng/mL, pLogRank=0.047) and FCN-3 (<4857 ng/mL, pLogRank=0.029), but not with MASP-2 deficiency (<100 ng/mL, pLogRank=0.306).
|
28109038 |
2017 |